from pytrials.client import ClinicalTrials
import ujson
import asyncio
import aiohttp
import sqlite3
from tqdm import tqdm
from datetime import datetime,timedelta
import os
from dotenv import load_dotenv
from concurrent.futures import ThreadPoolExecutor
import pandas as pd
import time



# Function to extract the string after the first 'DRUG:'
def extract_drug(string):
    parts = string.split('|')
    for part in parts:
        if part.startswith('DRUG:'):
            return part.split(': ', 1)[1].strip()  # Extract the part after 'DRUG:'
    return ''  # Return empty string if no 'DRUG:' found


ct = ClinicalTrials()

async def get_data(company_name):
	try:

		company_name = company_name.replace('&','and')
		get_ct_data = ct.get_study_fields(
		    search_expr=f"{company_name}",
		    fields=["Study Results","Interventions","Funder Type","Start Date", "Completion Date","Study Status","Study Title", 'Phases', 'Brief Summary', 'Age','Sex', 'Enrollment','Study Type','Sponsor','Study URL','NCT Number'],
		    max_studies=1000,
		    )
		df = pd.DataFrame.from_records(get_ct_data[1:], columns=get_ct_data[0])
		df['Start Date'] = pd.to_datetime(df['Start Date'],errors='coerce')
		df_sorted = df.sort_values(by='Start Date', ascending=False)

		df_sorted['Start Date'] = df_sorted['Start Date'].apply(lambda x: x.strftime('%Y-%m-%d') if pd.notnull(x) else None)
		df_sorted['Phases'] = df_sorted['Phases'].replace('PHASE2|PHASE3', 'Phase 2/3')
		df_sorted['Phases'] = df_sorted['Phases'].replace('PHASE1|PHASE2', 'Phase 1/2')
		df_sorted['Phases'] = df_sorted['Phases'].replace('EARLY_PHASE1', 'Phase 1')

		df_sorted['Study Status'] = df_sorted['Study Status'].replace('ACTIVE_NOT_RECRUITING', 'Active')
		df_sorted['Study Status'] = df_sorted['Study Status'].replace('NOT_YET_RECRUITING', 'Active')
		df_sorted['Study Status'] = df_sorted['Study Status'].replace('UNKNOWN', '-')

		df_sorted['Interventions'] = df_sorted['Interventions'].apply(extract_drug)
		data = df_sorted.to_dict('records')
		return data
	
	except Exception as e:
		print(f"Error fetching data for {company_name}: {e}")
		return []

async def save_json(symbol, data):
    # Use async file writing to avoid blocking the event loop
    loop = asyncio.get_event_loop()
    path = f"json/clinical-trial/companies/{symbol}.json"
    await loop.run_in_executor(None, ujson.dump, data, open(path, 'w'))

async def process_ticker(symbol, name):
    data = await get_data(name)
    if len(data)>0:
        await save_json(symbol, data)

async def run():
    con = sqlite3.connect('stocks.db')

    cursor = con.cursor()
    cursor.execute("PRAGMA journal_mode = wal")
    cursor.execute("SELECT DISTINCT symbol, name FROM stocks WHERE (industry = 'Biotechnology' OR industry LIKE '%Drug%') AND symbol NOT LIKE '%.%'")
    company_data = [{'symbol': row[0], 'name': row[1]} for row in cursor.fetchall()]
    con.close()
    #test mode
    #company_data = [{'symbol': 'MRK', 'name': 'Merck & Co. Inc.'}]
    print(len(company_data))
    async with aiohttp.ClientSession() as session:
        tasks = []
        for item in company_data:
            tasks.append(process_ticker(item['symbol'], item['name']))
        
        # Run tasks concurrently in batches to avoid too many open connections
        batch_size = 10  # Adjust based on your system's capacity
        for i in tqdm(range(0, len(tasks), batch_size)):
            batch = tasks[i:i + batch_size]
            await asyncio.gather(*batch)


if __name__ == "__main__":
    try:
        asyncio.run(run())
    except Exception as e:
        print(f"An error occurred: {e}")